Removal or inhibition of transglutaminase 2 decreases cellular stress, supporting tissue preservation, and recovery after SCI.

Statistical analysis of GRP78 expression confirmed a highly significant reduction (**** p < 0.0001) in GRP78 intensity in GFAP astrocytes (Fig. 10 D) and NeuN neurons (Fig. 10 E) of TG2 KO samples.

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MAP2 staining of neuronal dendrites and somata showed a trend for greater immunoreactivity in TG2 KO mice compared to TG2 intact mice that did not reach statistical significance (Fig. 6 A, D, G).

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