Suppressing Endothelial-Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study.

In the MS-275 (5 mg/kg) group, LVEDV showed a decreasing trend compared to the ISO group, although this did not reach statistical significance.

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Left ventricular posterior wall thickness at end-diastole (LVPWD) showed an increasing trend in the ISO group, although the difference compared to the CON group was not statistically significant.

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Notably, while the 50 mg/kg protocatechuic acid treatment (PCA-L group) showed a trend toward improvement compared to the ISO group, the difference was not statistically significant ( Figure 2 A,B).

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