Bioenergetic Signatures of DLD Deficiency: Dissecting PDHc- and α-KGDHc-Linked Defects.

Antioxidants (Basel) · 2025 · PMC12837974 · PMID 41596078

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0.0510

closest p · 1.0× alpha

0.0630

boldest claim

The sentences

a near-significant trendp = 0.051so close (0.05 < p ≤ 0.1)

While most patient-derived fibroblast lines showed comparable mtDNA levels to controls, Pt5 exhibited a significantly reduced mtDNA copy number, and Pt2 displayed a near-significant trend ( p = 0.051) toward lower mtDNA content ( Supplementary Figure S7 ).

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showed a trendp = 0.063so close (0.05 < p ≤ 0.1)

At routine respiration, Pt6 exhibited a significant reduction relative to control, while Pt1 and Pt2 (the most clinically severe) showed a trend toward lower rates ( p = 0.063; Figure 2 A).

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