Epigenetic Signatures in an Italian Cohort of Parkinson's Disease Patients from Sicily.

Brain Sci · 2025 · PMC12839038 · PMID 41594752

Europe PMC DOI

hedged sentences

0.0120

closest p · 0.2× alpha

0.0300

boldest claim

The sentences

showed a trendp = 0.012actually significant

Monocyte proportions showed a trend toward higher levels in the PD group (unadjusted p = 0.012, FDR-adjusted q = 0.141, 95% CI: 0.0045–0.0275), but the effect remains uncertain.

also in 31,039 other papers

nominally significantp = 0.03actually significant

However, among the 116 EpiScores, only CXCL10 showed a nominally significant difference ( p = 0.03 95% CI: 0.001–0.0188; Figure 1 ), but this did not remain significant after FDR adjustment, highlighting the uncertainty of small effect sizes. 3.5.

also in 4,457 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.