a significant trendp = 0.003
Although there was no clear trend for homozygosity, heterozygous carriers displayed a significant trend toward cognitive impairment according to the MOCA ( p = 0.003 for proportions comparison between groups), but for proportions analyzed based on RBANS and Linear Regression analysis, it did not reach statistical significance ( p > 0.1) ( Table 1 and Figure 2 ).