A PDCD4-Based Gene Expression Signature Predicts Overall Survival in Renal Cell Carcinoma: A TCGA-Based Discovery and External Validation Study.

Curr Issues Mol Biol · 2025 · PMC12840172 · PMID 41614853

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1520

boldest claim

The sentences

highly significantp = 4.5 × 10 −7actually significant

In contrast, the 100-gene PDCD4 signature demonstrated highly significant prognostic value (HR = 0.63, 95% CI: 0.53–0.75, p = 4.5 × 10 −7 , C-index = 0.621; Supplementary Figure S3 ), with significantly superior discriminative ability (likelihood ratio test p < 2.2 × 10 −16 ).

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borderline significantp = 0.054so close (0.05 < p ≤ 0.1)

Grade 1–2) showed a borderline significant association (HR = 1.51, 95% CI: 1.00–2.29, p = 0.054), while male gender demonstrated a trend toward better survival that did not reach statistical significance (HR = 0.73, 95% CI: 0.52–1.01, p = 0.059).

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did not reach statistical significancep = 0.152not close (p > 0.1)

showed a trendp = 0.152not close (p > 0.1)

While PDCD4 expression showed a trend toward better survival in high-expressing patients, it did not reach statistical significance (HR = 0.97, 95% CI: 0.94–1.01, p = 0.152, C-index = 0.589; Supplementary Figure S3 ).

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