Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors.

Data reported in Figure 4 b revealed an overall higher level of circulating ligand in the melanoma group, although the difference did not reach statistical significance, possibly due to the small sample size. 2.5.

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Sonidegib at 10 μM showed a trend toward reducing the number of Ki67-positive cells compared to vehicle.

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