<i>Dnmt3b</i> Deficiency in Adipocyte Progenitor Cells Ameliorates Obesity in Female Mice.

Unlike the lean phenotype observed in female PD3bKO mice, male PD3bKO mice fed a HFD exhibited a trend toward higher body weight, though it did not reach statistical significance ( Figure 5 A).

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We found that Esr1 expression was increased in all fat depots of female PD3bKO mice ( Figure 6 A), whereas in male PD3bKO mice, Esr1 expression was increased only in iBAT and showed a trend toward elevation in iWAT ( Figure 6 B). 3.

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