Impact of <i>UGT1A1*28</i> Allele on the Safety and Effectiveness of Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer: Real-World Evidence.

J Clin Med · 2026 · PMC12842121 · PMID 41598512

Europe PMC DOI

hedged sentences

0.7820

closest p · 15.6× alpha

0.7820

boldest claim

The sentences

did not reach statistical significancep = 0.782not close (p > 0.1)

Among HomoMut patients, the median PFS was 9.1 months for those receiving the full dose and 15.2 months for those requiring dose reduction; however, this difference did not reach statistical significance ( p = 0.782).

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a clear trendno p-value reported

The rate of grade ≥ 2 febrile neutropenia was higher among HomoMut patients and, although no statistically significant differences were observed in the other AEs analyzed, there was a clear trend toward a greater toxicity in the HomoMut group, particularly in terms of grade ≥ 2 diarrhea and anemia.

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