Efficacy and Safety of Newly Diagnosed Multiple Myeloma Combination Therapies: A Systematic Review Integrating Network Meta-Analysis and Real-World Vigilance Study.

Furthermore, an improvement in ORR was also observed for D_KRd (OR = 2.38, 95% CI: 0.75–9.48) and D_VTd (OR = 2.14, 95% CI: 0.78–5.9), although these differences did not reach statistical significance ( Supplementary Figures S4 and S5 ).

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However, while most regimens showed a trend toward OS benefit, none reached statistical significance compared to VRd ( Supplementary Figures S8 and S9 ), indicating that longer-term follow-up data are required to confirm their definitive impact on OS.

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