Barely Significant
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In Vitro and In Silico Evaluation of Polymyxin B Aerosol Delivery in Adult Mechanical Ventilation.

Pharmaceutics · 2025 · PMC12845456 · PMID 41599165

2
hedged sentences
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

highly significantp < 0.0001actually significant
The results showed highly significant main effects (all p < 0.0001, Supplementary Material Table S4 ) regarding nebulizer type, placement position, and artificial airway type.

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did not reach statistical significancep = 0.309not close (p > 0.1)
showed a trendno p-value reported
In this standalone setting, the VMN, with its higher aerosol output rate and superior aerosol characteristics (lower MMAD and higher FPF), as also reported in the literature [ 27 , 28 , 29 ], showed a trend toward slightly higher drug delivery compared to the JN, although this difference did not reach statistical significance ( p = 0.309).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.