Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma.

Groups treated with ketotifen + dacarbazine or sonopermeation + dacarbazine showed trends toward reduced tumor mass, though these did not reach statistical significance ( Fig. 3 C).

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Ketotifen + oxaliplatin showed a trend toward higher Granzyme B levels compared to control, and sonopermeation + oxaliplatin was significantly elevated relative to both control and oxaliplatin groups.

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The levels of IL-10, an immune suppressive cytokine produced by regulatory T cells and Th1 cells [ 100 ], revealed a decreasing trend in the triple therapy group compared to the other groups.

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