Inhibitory GABAergic Neuron Loss due to Oxidative Damage During Ex Vivo Acute Brain Slice Preparation Influences Genesis and Dynamics of Epileptiform Activity.

J Neurochem · 2026 · PMC12848643 · PMID 41603127

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0.0700

closest p · 1.4× alpha

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The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

As predicted, carbonyl concentration in the brain slices is reduced in the antioxidant‐treated brain slices, although this did not reach statistical significance (unpaired two‐tailed t ‐test, t (15) = 1.94, p = 0.07).

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showed a trendno p-value reported

Interestingly, the time to induce SLEs is not significantly different (one‐way ANOVA, F (3,26) = 2.21, p = 0.1109) between the different brain slice preparation methods, although slices prepared using DN methods showed a trend towards an earlier SLE induction time, as in the 0 Mg 2+ model.

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