Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression.

Il1b transcript levels showed a trend toward increase in 24-month-old animals, but this did not reach statistical significance (Fig. 4 b; age: p = 0.0731; Supplementary Fig. 5b).

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24-month-old animals swam significantly slower than those in the 18-month-old cohort, while APP-overexpressing mice showed a trend toward increased swim velocity (Fig. 1 i).

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