GPR43 deficiency aggravates sepsis by promoting gut microbiota-dependent barrier disruption and HIF-1α-ENO1 axis-mediated M1 polarization of macrophages.

Cell Mol Biol Lett · 2025 · PMC12849540 · PMID 41444511

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Conversely, WT mice transplanted with Gpr43 −/− microbiota showed a trend toward reduced survival, although this did not reach statistical significance (Fig. 2 K).

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