Barely Significant
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<i>RIN3</i> mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.

Sci Adv · 2026 · PMC12851038 · PMID 41604486

Europe PMCDOI
3
hedged sentences
0.0030
closest p · 0.1× alpha
0.0760
boldest claim

The sentences

highly significantP = 0.003actually significant
Notably, hiNs containing both RIN3 mutations (RQPS) showed a highly significant elevation in active RAB5* levels ( n = 3, P = 0.003) compared to the R427Q mutation, possibly synergistically, in the presence of the P477S mutation.

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nominally significantP = 0.035actually significant
Notably, in an analysis of a multiethnic dataset with unrelated AD cases and controls from the Alzheimer’s disease sequencing project (ADSP; Table 1 ), rs74074811 showed nominally significant association of these same two RIN3 mutations with AD risk in the Hispanic population ( P = 0.035).

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did not reach statistical significanceP = 0.076so close (0.05 < p ≤ 0.1)
In contrast, the increase in RAB5* levels in cells containing only the RIN3 (PS) mutation was modest and did not reach statistical significance ( n = 3, P = 0.076).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.