Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity.

In addition, sCR1 showed a negative association with platelet count but which did not reach statistical significance, implicating that its suggestive role is more closely related to dengue severity than to thrombocytopenia.

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Significant negative associations were observed with red cell distribution width (RDW) and peripheral basophil counts ( P = 0.003 and P < 0.0001, respectively), whereas sCR1 showed a negative trend but was not statistically significant ( P = 0.056).

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