TP53 mutation predict poor prognosis in diffuse large B-cell lymphoma: a single-center study.

Ann Hematol · 2026 · PMC12855322 · PMID 41609884

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.1980

boldest claim

The sentences

a strong trendP = 0.074so close (0.05 < p ≤ 0.1)

Additionally, a VAF ≥ 53% was a significant risk factor for OS ( P = 0.007) and showed a strong trend for PFS ( P = 0.074).

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did not reach statistical significanceP = 0.198not close (p > 0.1)

However, the test for interaction between TP53 mutation and DEL status did not reach statistical significance (OS: P = 0.198; PFS: P = 0.568; Supplemental Table S6 ), suggesting that their combined effect may be additive rather than synergistic.

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