Clinical outcomes of SGLT2 inhibitor use in Thai patients with heart failure: a five-year retrospective cohort study.

Int J Cardiol Heart Vasc · 2026 · PMC12856583 · PMID 41624494

Europe PMC DOI

hedged sentences

0.3270

closest p · 6.5× alpha

0.3270

boldest claim

The sentences

did not reach statistical significancep = 0.327not close (p > 0.1)

Although there was a favorable trend toward reduced HF hospitalization in the SGLT2i group, the difference did not reach statistical significance (adjusted RR 0.83, 95% CI: 0.58–1.20; p = 0.327) ( Fig. 2 ).

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a favorable trendno p-value reported

The all-cause mortality rate in the SGLT2i group was markedly lower (rate ratio 0.02, 95% CI: 0.00–0.18; p = 0.001), while heart failure hospitalization showed a favorable trend without reaching statistical significance.

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showed a trendno p-value reported

Meanwhile, IPTW analysis showed a trend towards lower risk of the composite outcome in the SGLT2i group compared with non-SGLT2i group, but the difference was not statistically significant (adjusted RR 0.90, 95% CI: 0.55–1.49; p = 0.688) ( Table 3B ).

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