Barely Significant
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Integration of <i>PNPLA3</i> and <i>TM6SF2</i> genotypes provides incremental improvement in advanced fibrosis prediction among MASLD patients with type 2 diabetes mellitus.

JHEP Rep · 2026 · PMC12857344 · PMID 41624490

Europe PMCDOI
3
hedged sentences
0.0580
closest p · 1.2× alpha
0.0580
boldest claim

The sentences

a favorable trendp = 0.058so close (0.05 < p ≤ 0.1)
In the T2DM subgroup (n = 121), genotype incorporation led to small but statistically significant improvements in discrimination for NFS (AUROC increase: 0.053, p = 0.001) and FIB-4 (AUROC increase: 0.058, p = 0.010), while Agile 3+ showed a favorable trend (AUROC increase: 0.016, p = 0.058).

also in 1,335 other papers

did not reach statistical significanceno p-value reported
For the already high-performing Agile 3+ model, a similar trend of improvement was observed, although it did not reach statistical significance.

also in 111,027 other papers

showed a trendno p-value reported
These results showed a trend similar to that observed in the test cohort.

also in 53,322 other papers

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