The link between GABA levels and P300 abnormalities in schizophrenia spectrum disorders: regional and symptom-based insights.

Schizophrenia (Heidelb) · 2026 · PMC12859150 · PMID 41577705

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0.0590

closest p · 1.2× alpha

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did not reach statistical significancep = 0.059so close (0.05 < p ≤ 0.1)

Metabolite comparisons No significant group effects were observed for GABA or Glx in the ACC, nor for Glx in the lDLPFC (all p s > 0.05) when comparing HC and overall SSD, although there was a trend toward higher lDLPFC GABA levels in patients, it did not reach statistical significance ( F (1, 94) = 3.65, p = 0.059; mean HC = 1.25, mean SSD = 1.39) (see Fig. 3a ).

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showed a trendno p-value reported

SSD+ exhibited widespread P3b amplitude reductions, significant at parietal and trend-level at central and frontal regions, while SSD− showed a trend-level amplitude reduction limited to the parietal region.

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