Correlative imaging reveals metal dyshomeostasis and altered zinc coordination environments in a pre-clinical Type 2 diabetes model.

Metallomics · 2026 · PMC12859259 · PMID 41481137

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significanceP = 0.06so close (0.05 < p ≤ 0.1)

Diabetic peri-islet regions tended towards decreased Cu in young animals and increased Cu in old animals compared to their non-diabetic, age-matched controls, resulting in a 1.8-fold difference between them that approached significance ( P = 0.06).

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did not reach statistical significanceno p-value reported

Iron Iron (Fe) was elevated in peri-islet and exocrine regions of Db compared to Het animals (1.9-fold, P < 0.01 and 1.5-fold, P < 0.01, respectively), though individual age-group differences did not reach statistical significance.

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