Serial next-generation sequencing for detecting germline predisposition in acute myeloid leukemia.

Haematologica · 2026 · PMC12862303 · PMID 40605710

Europe PMC DOI

hedged sentences

0.0340

closest p · 0.7× alpha

0.9890

boldest claim

The sentences

showed a trendP =0.034actually significant

Overall survival showed a trend toward worse prognosis in patients with germline mutations ( P =0.034); however, this difference did not reach statistical significance in multivariate analysis that included age, 2022 ELN risk classification, and allogeneic HCT status (hazard ratio =1.00; 95% confidence interval: 0.53-1.86; P =0.989) ( Online Supplementary Figure S2 ).

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did not reach statistical significanceP =0.989not close (p > 0.1)

Overall survival showed a trend toward worse prognosis in patients with germline mutations ( P =0.034); however, this difference did not reach statistical significance in multivariate analysis that included age, 2022 ELN risk classification, and allogeneic HCT status (hazard ratio =1.00; 95% confidence interval: 0.53-1.86; P =0.989) ( Online Supplementary Figure S2 ).

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