A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.

Our findings suggest that MDD and PTSD show marginally significant ( β = 0.10, SE = 0.06, p = 0.07) and non-significant ( β = −0.07, SE = 0.14, p = 0.644) associations with migraine, respectively, while TBI, even after accounting for MDD and PTSD (which are genetically correlated, r g = 0.64, SE = 0.03), maintains a strong association ( β = 0.75, SE = 0.12, p < 0.001).

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Loci that contained at least one SNP that was nominally significant (after Bonferroni correction for 36 loci tested: p < 0.05/36) were classified as ‘novel-replicated’.

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Non-European analyses were similarly underpowered, with no GWS loci identified in AFR men or HIS women, although some loci approached significance.

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