Perivascular pathology, not macrovascular complexity, governs glymphatic-related dysfunction in preclinical cerebral small vessel disease.

Sci Rep · 2026 · PMC12867987 · PMID 41530513

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0840

boldest claim

The sentences

showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

WMI showed a trend toward a positive association with DTI-ALPS (β = 0.252, p = 0.054), and PSI showed a borderline negative association (β =–0.277, p = 0.056), though both were just above the conventional significance threshold.

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did not reach statistical significancep = 0.084so close (0.05 < p ≤ 0.1)

Participants with ePVS tended to be older (mean age: 42.77 ± 13.11 years) compared to those without ePVS (37.59 ± 9.71 years), although this difference did not reach statistical significance (t [58] = 1.76, p = 0.084).

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