A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma.

Front Allergy · 2025 · PMC12868147 · PMID 41647190

Europe PMC DOI

hedged sentences

0.0004

closest p · 0.0× alpha

0.0004

boldest claim

The sentences

showed a trendp = 0.0004actually significant

However, differential abundance analysis showed a trend toward increased Bifidobacterium in the SCF group compared to placebo (ANCOM-BC p = 0.0004, FDR q = 0.073).

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did not reach statistical significancep = 0.0004actually significant

were elevated in participants receiving SCF compared to placebo, but this did not reach statistical significance after correcting for multiple comparisons ( p = 0.0004, FDR q = 0.073, ANCOMBC).

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an overall trendno p-value reported

This finding aligns with several studies and a recent meta-analysis, which demonstrated an overall trend of increased Bifidobacterium and other taxa across multiple studies of fiber supplementation ( 23 – 25 , 52 ).

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