Dual antiplatelet therapy use after non-cardioembolic ischemic stroke or transient ischemic attack: a meta-analysis of trials and cohort studies.

Front Neurol · 2025 · PMC12869719 · PMID 41647791

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

approached significancep = 0.05actually significant

The between-group comparison approached significance ( p = 0.05), suggesting a potential design-related difference that may reflect more rigorous event adjudication and reporting in trials than in observational studies.

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did not reach statistical significancep = 0.32not close (p > 0.1)

a numerical trendno p-value reported

Although the difference did not reach statistical significance ( p = 0.32), there was a numerical trend toward higher bleeding risk with ASA-CLOP combination (pRR 1.51; 95% CI 1.01–2.25) compared with non-ASA-CLOP regimens (pRR 1.16; 95% CI 0.85–1.59).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.