Impact of time-restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high-fat diet-induced obesity.

J Physiol · 2026 · PMC12871908 · PMID 41491637

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did not reach statistical significanceno p-value reported

Although the difference did not reach statistical significance, TRF partially reversed HFD‐induced insulin resistance, suggesting some improvement in insulin sensitivity.

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an increasing trendno p-value reported

Per1 expression showed an increasing trend with HFD, which was significantly reduced by TRF (Fig. 8 D ).

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showed a trendno p-value reported

TRF significantly reduced heart weight and showed a trend towards lower liver and kidney weights compared to HFD‐AL mice (Fig. 2 F ).

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