High-fat Western diet induces retinal and metabolic alterations in APOE3 and APOE4 knock-in mice.

Sci Rep · 2026 · PMC12873366 · PMID 41507267

Europe PMC DOI

hedged sentences

0.0562

closest p · 1.1× alpha

0.0571

boldest claim

The sentences

a strong trendp = 0.0562so close (0.05 < p ≤ 0.1)

WD-fed APOE3 mice had higher total cholesterol than APOE3 CD mice ( p = 0.0108), while APOE4 WD mice showed a strong trend toward higher cholesterol compared with APOE4 CD mice ( p = 0.0562; Supplemental Fig. 2 C).

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did not reach statistical significancep = 0.0571so close (0.05 < p ≤ 0.1)

Il1b levels in APOE4 WD mice also tended to be higher than in APOE4 CD mice, although this comparison did not reach statistical significance ( p = 0.0571).

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