Evaluating cardiac echocardiographic changes with levothyroxine in hypothyroid patients: a systematic review and meta-analysis.

Front Endocrinol (Lausanne) · 2025 · PMC12875953 · PMID 41659340

Europe PMC DOI

hedged sentences

0.0791

closest p · 1.6× alpha

0.0791

boldest claim

The sentences

approached significancep=0.0791so close (0.05 < p ≤ 0.1)

Furthermore, the test for subgroup differences by disease type for LVEF approached significance (Q = 6.78, p=0.0791), suggesting that the varying cardiac responses to L-T4, while numerically distinct, did not reach statistical significance between disease types at this level of analysis.

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did not reach statistical significancep=0.0791so close (0.05 < p ≤ 0.1)

While distinct trends were observed, the formal test for subgroup differences approached but did not reach statistical significance (Q = 6.78, p=0.0791), suggesting that the varying cardiac responses to L-T4 intervention, while numerically different across disease types, were not statistically distinct at the subgroup level in this analysis.

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