Diabetes mellitus was not associated with RAP, but showed a nonsignificant trend toward an increased risk of CP (OR, 3.77; 95% CI, 0.98–14.45; 95% PI, 0.12–120.85; I 2=0%, τ2=0; k=4 studies, N=169 patients) ( Figs. 3 and 4 ; Supplementary Figs. 2 , 4 , and 6 ).
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Progression from acute to chronic pancreatitis in children: a systematic review and meta-analysis.
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Disease severity showed a trend toward higher recurrence rates, although subgroup differences were not statistically significant (χ2=2.60, degrees of freedom [df]=2, P =0.272).
Interestingly, mutations in SPINK1, CFTR, and CTRC, which have been previously implicated in pancreatitis susceptibility, did not reach statistical significance in our analysis.