Association Between Positive End-Expiratory Pressure at Venovenous Extracorporeal Membrane Oxygenation Initiation and Liberation Outcomes in Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study.

Crit Care Explor · 2026 · PMC12879967 · PMID 41642671

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did not reach statistical significanceno p-value reported

Restricting analyses to subgroups such as morbid obesity (BMI ≥ 30 kg/m 2 ), exclusion of interstitial pneumonia, pulmonary-etiology ARDS, Murray score greater than or equal to 2.5, COVID-19, and age strata yielded overall consistent results; however, the association did not reach statistical significance within the morbid obesity subgroup ( Tables S4–S9 , https://links.lww.com/CCX/B600 ).

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showed a trendno p-value reported

Sensitivity Analyses Sensitivity analysis using an alternative PEEP classification (low < 6 cm H 2 O, middle 6–10 cm H 2 O, and high > 10 cm H 2 O) showed a trend toward lower ECMO liberation in the low group, although not statistically significant (HR, 0.56; 95% CI, 0.31–1.01; Table S1 , https://links.lww.com/CCX/B600 ).

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