Ligand-receptor pair-based signature score derived from on-treatment tumor specimens predicts immune checkpoint blockade response in metastatic melanoma.

Discov Oncol · 2026 · PMC12881185 · PMID 41511734

Europe PMC DOI

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a clear trendno p-value reported

did not reach statistical significanceno p-value reported

Although the OS difference in the MGH cohort did not reach statistical significance, a clear trend toward improved survival was still observed in the high-LRPS group, suggesting consistent biological relevance across cohorts.

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