A novel synbiotic (SCM06) for anxiety and sensory hyperresponsiveness in children with autism spectrum disorder: an open-label pilot study.

NPJ Biofilms Microbiomes · 2026 · PMC12881606 · PMID 41535300

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0990

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

Although symptoms of abdominal pain, anxiety, and sensory hyperresponsiveness did not reach statistical significance in explaining overall metabolome variance ( p > 0.05), PERMANOVA analysis revealed a marginal shift in overall metabolome after treatment (pseudo-F = 2.05, R2 = 0.029, p = 0.061, Fig. 4A & B ).

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marginally significantp = 0.099so close (0.05 < p ≤ 0.1)

The baseline-by-time interaction for assessing regression to the mean (RTM) was marginally significant for anxiety ( p = 0.099) but not for sensory hyperresponsiveness ( p = 0.435), indicating minimal RTM influence.

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nominally significantno p-value reported

Although no associations survived FDR correction (all p _adj > 0.25), nominally significant correlations were observed between improvements in anxiety and sensory hyperresponsiveness and changes in multiple species.

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