Real world clinical practice of lecanemab at PUMCH dementia cohort: focus on dynamic imaging and biomarker evolution.

Alzheimers Res Ther · 2026 · PMC12882609 · PMID 41520099

Europe PMC DOI

hedged sentences

0.2200

closest p · 4.4× alpha

0.2200

boldest claim

The sentences

did not reach statistical significancep = 0.22not close (p > 0.1)

Their pre-treatment centiloid values were lower compared to the non-conversion group, but the difference did not reach statistical significance (49.8 ± 25.0 versus 61.5 ± 20.9, p = 0.22).

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showed a trendno p-value reported

Furthermore, both the MMSE and MoCA scores showed a trend toward worsening; although these changes did not reach statistical significance.

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highly significantno p-value reported

The attenuated amyloid clearance in homozygotes is a highly significant observation.

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a decreasing trendno p-value reported

The results showed a decreasing trend in both the left and right ALPS indices after six months of treatment, though these changes did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.