Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease.

Finally, relative fat intake reached significance in the survival analysis (HR (95% CI) = 0.95 (0.93, 0.98), p = 3.46 × 10 −5 ) and borderline significance in the LMM analysis (beta(95% CI) = 0.24 (0.09, 0.39), p = 0.002).

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In contrast, PGS for individual saturated, unsaturated, and total fatty acid components did not reach statistical significance, except LMM analysis of PGS for total fatty acid levels showed potential association with AAO of AD (beta (95% CI) = ‐0.16 (‐0.29, ‐0.02), p = 0.028) (Table S1 ).

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However, T2D still showed nominally significant (IVW p = 0.046, MR‐EGGER p = 0.026).

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