Comparative Study of the Efficacy of Ranolazine as Add-On Therapy With Metformin Versus Metformin Monotherapy on Glycaemic Control in Patients of Type 2 Diabetes Mellitus.

Cureus · 2026 · PMC12884675 · PMID 41669572

Europe PMC DOI

hedged sentences

0.0501

closest p · 1.0× alpha

0.0501

boldest claim

The sentences

borderline significantp = 0.0501so close (0.05 < p ≤ 0.1)

While the difference in post-prandial blood glucose (PPBG) at three months was borderline significant (p = 0.0501), it became clearly significant by six months (p = 0.027).

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showed a trendp = 0.0501so close (0.05 < p ≤ 0.1)

At three months, the combination group showed a trend toward lower PPBG levels, approaching statistical significance (p = 0.0501).

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narrowly missed statistical significanceno p-value reported

Although the absolute HbA1c change over six months showed a favourable trend in the combination group, it narrowly missed statistical significance.

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near-significantno p-value reported

Multivariable regression analysis further confirmed that longer diabetes duration, higher LDL levels, and elevated baseline HbA1c were significant predictors of HbA1c change, while the treatment group showed a near-significant independent effect.

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