Genetically-Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model.

[ 59 , 60 , 61 , 62 ] Over the course of the study, all treated mice showed a trend for reduced weight loss compared to sham control, with ≈10% weight loss at Day 7 for sham versus ≈5% for all three treatment groups (ns) ( Figure 6 A ).

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Trends for reduced weight loss were also observed for these BEV treatment groups, but differences did not reach statistical significance ( Figure 3 A,B ).

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