Effects of MAO-B and COMT Inhibitors on Sleep Disturbances in Patients With Parkinson's Disease: A Network Meta-Analysis.

However, these effects failed to reach statistical significance, emphasizing the need for cautious interpretation and highlighting the persistent limitations in subjective sleep evaluation methods, which may be prone to reporting bias or a lack of sensitivity in capturing nuanced changes.

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Similarly, although none of the treatments demonstrated statistically significant effects, a numerical trend favoring rasagiline, safinamide, and rasagiline ER 0.75 mg over placebo was observed in the analysis of subjective daytime sleepiness measures.

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While these findings did not reach statistical significance, the consistent direction of the effect is clinically relevant.

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