PFKFB2 Is Pivotal for Metabolic Flexibility and Differential Glucose Utilization.

37 Here, we observed that in control mice, there was a slight trend toward a decrease in blood glucose levels following 12 hours of fasting that reversed to trend toward an increase with acute stress (Figure 5B and 5C ).

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In cKO hearts, there were fasting‐induced decreases in both Akt and phosphorylated Akt, though these failed to reach statistical significance.

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While differences in liver glycogen between genotypes with stress did not reach statistical significance, there was a negligible amount of glycogen remaining in livers of stressed and fasted cKO mice (2.88% of that present in unstressed, fed control mice; Figure 5H ).

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