Multiarm multistage randomised controlled trial of inflammatory signal inhibitors (MATIS) for patients hospitalised with COVID-19 pneumonia during the UK pandemic.

BMJ Open · 2026 · PMC12887464 · PMID 41644167

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showed a trendno p-value reported

FOS also showed a trend in reducing COVID-19-related mortality and morbidity.

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did not reach statistical significanceno p-value reported

The complier-adjusted RD estimates were slightly further away from the null than the corresponding ITT analyses but did not reach statistical significance (complier adjusted vs ITT: FOS vs SOC: RD 0.05 vs 0.03; RUX vs SOC: RD −0.10 vs −0.06).

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