Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress.

Isolated islets from these older mice showed reduced GSIS in response to 20 mM glucose (G20), although their basal insulin secretion under 2.8 mM glucose (G2.8) only displayed a weak trend of reduction ( p = 0.27) ( Fig. 1 D ).

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In addition, a strong trend of improved glucose clearance is observed in young males ( Fig. 3 G ), without affecting their body weight ( Fig. 3 H ).

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Under regular feeding conditions, Myt3 IM/IM mutant mice with increased Myt3 production showed a trend of improving the glucose-clearing capacity in male mice, consistent with the positive roles of this gene in β-cell function.

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