Preclinical assessment of oral TLR7 agonist SA-5 in a nonhuman primate model.

Although frequency-based analyses at 3 mg/kg did not reach statistical significance, median values and CD80 MFI indicated activation consistent with IFN-α induction.

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In contrast, regarding IFN-α as an efficacy marker, the SA-5 group showed a trend toward induction 1 d after dosing, while the GS-9620 group demonstrated no clear induction (“blip”) ( Figure 6B ).

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