Two-year real-world experience with somatrogon in children and adolescents with growth hormone deficiency.

Front Endocrinol (Lausanne) · 2026 · PMC12890668 · PMID 41685229

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.060so close (0.05 < p ≤ 0.1)

Consistently with previous rhGH exposure in the Switch group, which had a median treatment duration of 1.7 years and a median rhGH dose of 28.9 mcg/kg/day before transitioning, baseline IGF-1 levels were higher in the Switch group (-0.60 SDS [-1.15;0.92]) than in the Naïve group (-1.05 SDS [-1,73;-0.58]), although the difference did not reach statistical significance ( p = 0.060).

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a negative trendno p-value reported

The difference between bone age and chronological age again showed a negative trend, consistent with the 6-month findings.

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