A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1<sup>-/y</sup> mice.

Comparing Pk1a maximum power across genotypes revealed a strong trend supporting the bootstrapped spectrum results (Fig. 6r ; uncorrected p -value = 0.02), with no apparent difference in Pk1b maximum power (Fig. 6t ) nor the center frequency of either subpeak (Fig. 6q, s ).

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Arbaclofen increased Pk1a power at both doses and significantly decreased its center frequency at the higher dose (with a clear trend at the lower dose).

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