Role of Prophylactic Negative Pressure Wound Therapy in Reducing Surgical-Site Infections in Spine Surgery - A Systematic Review and Meta-Analysis.

Global Spine J · 2026 · PMC12893932 · PMID 41670395

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

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boldest claim

The sentences

did not reach statistical significanceP = 0.05actually significant

The pooled effect did not reach statistical significance (OR = 0.68, 95%CI(0.39-1.18), P = 0.05; I 2 = 57%) as shown in Figure 3A .

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near-significantP = 0.07so close (0.05 < p ≤ 0.1)

In the most up-to-date systematic review and meta-analysis by Rathore et al, 47 a 55% reduction in SSI risk (OR 0.45, 95% CI 0.29-0.72; P < 0.001) and near-significant reduction in dehiscence rates (OR 0.53, 95% CI 0.26-1.06; P = 0.07), thereby supporting its prophylactic adoption in posterior spinal surgeries.

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