In vivo imaging of glutamate uncovers the neuroprotective effects of nicotinamide riboside on excitotoxicity in an Alzheimer's mouse model.

For the hippocampus, a supplement effect was detected at a p = 0.06, indicating a trend towards significance and suggesting that NR supplementation may increase NAD + levels regardless of disease type.

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Furthermore, a decrease in GluCEST in AD mice following treatment was detected with F(1, 14) = 4.8, p = 0.06), but did not reach statistical significance.

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NAD + assays performed in this study showed a trend towards higher hippocampal NAD + levels following NR supplementation, although this increase did not reach statistical significance.

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