Accelerometer-derived physical activity patterns and risk of incident gout: a prospective cohort study of 97,387 UK Biobank participants.

Arthritis Res Ther · 2025 · PMC12896187 · PMID 41454374

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.1080

boldest claim

The sentences

failed to reach statistical significanceP > 0.05actually significant

In contrast, the association for the WW pattern was consistently attenuated and failed to reach statistical significance in Model 3 across these sensitivity analyses (all P > 0.05).

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marginally significantP = 0.079so close (0.05 < p ≤ 0.1)

Although this difference was marginally significant ( P = 0.079), it indicates that the regularly active pattern may confer superior protection compared to the weekend warrior pattern, potentially due to the sustained physiological benefits of consistent physical activity.

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did not reach statistical significanceP = 0.108not close (p > 0.1)

Although the RA group showed a lower cumulative incidence compared with the WW group, the difference did not reach statistical significance ( P = 0.108).

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a favorable trendno p-value reported

Conversely, the RA pattern maintained a favorable trend towards risk reduction even among those with comorbidities (Hypertension: HR = 0.75; CKD: HR = 0.59), suggesting that regular physical activity may be necessary to be associated with lower risk in populations with compromised metabolic or renal health.

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