Recombinant Human IgG1-Hexamer Reduces Pathogenic Autoantibodies in the K/BxN Mouse Model of Arthritis Independent of FcRn.

Int J Mol Sci · 2026 · PMC12897602 · PMID 41683705

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showed a trendno p-value reported

CXCL2 (MIP2) was increased in HSA control relative to KRN and showed a trend downwards with Fc-μTP-L309C treatment, although this was not significant.

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did not reach statistical significanceno p-value reported

BAFF levels in peripheral blood did not change; however, there was a decrease in the joint fluid after Fc-μTP-L309C treatment compared to HSA, from mean value of 350 pg/mL to 150 pg/mL; however, this did not reach statistical significance. 3.

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