Functional and Epigenomic Consequences of <i>DNMT1</i> Variants in Inherited Neurological Disorders.

However, these differences did not reach statistical significance (one-way ANOVA) ( Figure 2 C). 2.5.

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Western blot analysis of whole-cell lysates showed a trend toward reduced DNMT1 protein levels across all variants, with the largest decreases observed for p.Y511H and p.H569R relative to WT DNMT1.

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